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Different points of view will give you different answers. Commonly we think of disease as bacteria or harmful pathogens or free radicals entering the body, causing a disruption in homeostasis (body's ability to maintain balance). Another viewpoint will tell you those bacteria, pathogens, free radicals, etc, were always there, however a compensatory pattern in lifestyle (i.e.too much coffee, soda, fatty foods leads to acidosis of the blood, causing numerous common problems) has caused an imbalance, physically, emotionally or mentally, and thus providing an environment that the disease can flourish.

Diseases are called by pathogens. These can be bacterias, viruses, protists, fungi, or parasites.

Disease causing microorganisms and body's immune system.

Many things can cause disease including but not limited to bacteria, viruses, parasites, toxins, injury, accidents, and stress. Each may cause disease via a different mechanism which could be a topic for a new question.

The question is very broad, because there are many causes of diseases, including:

  • genetics
  • pathogens - bacteria, viruses
  • environmental, such as filth or unclean drinking water
  • lifestyle choices - example, Alcoholism can cause pancreatic disease, kidney disease, liver disease
  • nutritional - certain diseases arise from a lack of a specific nutrient, examples: scurvy; Diabetes which is also partly genetic
  • idiopathic - meaning, cause unknown

Or internal causes such as some hereditary factor.

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