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Long-term use of methadone can lead to several effects, including physical dependence and potential addiction, which may require increasingly higher doses to achieve the same effects. Chronic use can result in respiratory issues, cardiovascular problems, hormonal imbalances, and gastrointestinal disturbances. Additionally, individuals may experience cognitive impairments and emotional disturbances. Methadone can also interact negatively with other medications, complicating treatment and increasing the risk of overdose.

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