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Studies have shown that those with type A blood have a higher risk of Heart disease, of certain cancers, such as those of the pancreas, stomach, and esophagus, and a higher risk of contracting smallpox. Individuals with type O blood are at a higher risk for developing duodenal and peptic ulcers, as well as for contracting cholera and plague. Those with type O blood also tend to attract more mosquitoes, which could result in higher rates of malaria.

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