CAA may be found during an autopsy in over one-third of persons over age 60, even though they may not have had brain hemorrhage, stroke, or other manifestations of the disease during life.
The most common form of CAA is the sporadic form associated with aging. This type of CAA usually causes lobar hemorrhage, which may recur in different lobes of the brain.
Pontine hemorrhage is primarily caused by high blood pressure, which can lead to the rupture of small blood vessels in the pons region of the brain. Other potential causes include trauma, arteriovenous malformations, and bleeding disorders. Additionally, conditions such as cerebral amyloid angiopathy and certain drug use (e.g., anticoagulants) can also increase the risk of hemorrhage in the pons. Prompt medical attention is critical, as this type of hemorrhage can lead to severe neurological deficits or death.
A disorder marked by deposition of amyloid in the body. a rare disease which causes the build-up of amyloid, a protein, & starch, it can get in tissues and organs.
Cerebral cortex is the outer layer of the brain. Having a brain that is capable of a variety of brain function "causes" the cerebral cortex!
Sporadic ALS has no known cause. While many environmental toxins have been suggested as causes, to date no research has confirmed any of the candidates investigated, including aluminum and mercury and lead from dental fillings.
cerebral palsy
the right cerebral cortex
In hereditary CAA, genetic defects, typically on chromosome 21, allow accumulation of amyloid, a protein made up of units called beta-pleated sheet fibrils. The fibrils tend to clump together, so that the amyloid cannot be dissolved.
Temporal lobe
What causes cerebral palsy can vary in case to case. Sometimes it can be caused by mistakes made during delivery, other times it is caused my malformation within the womb.
Familial means hereditary, running in families, hence predictable at times. Sporadic means randomly caused, with no heredity that an be traced, usually by a mutation in the same gene that causes the familial form of the disorder.
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