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Spots on the liver can be signs of several conditions, including, but not limited to, Liver Cancer, Granuloma, Liver Adenoma, or Hemangioma. Of these, Liver Cancer is the most serious and life threatening possible cause of spots on the liver. Spots resulting from Granuloma are the cause of inflamed tissue resulting from infections involving the liver, such as tuberculosis. Liver Adenoma is a noncancerous tumor that most frequently affects women taking oral contraceptives. Hemangiomas are also a type of noncancerous liver tumor that are composed of abnormal blood vessels that form while in the womb, though they can appear at any age and are rarely a cause of symptoms.

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