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Technically, most named digestive enzymes and secretions are made by glands located outside of the "tube" of the gastrointestinal tract. For instance, the salivary glands are located between the muscles of the jaw and face, and secrete saliva into the mouth through salivary ducts. Bile is created by the liver, stored in the gallbladder and then secreted into the small intestine; pancreatic enzymes (there are a bunch of them) are made in the pancreas then secreted into the small intestine as well.

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