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Several diseases can affect the digestive system, including gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), and inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Other conditions include celiac disease, which is an autoimmune disorder triggered by gluten, and various infections such as gastroenteritis caused by viruses or bacteria. Additionally, liver diseases like hepatitis and cirrhosis can impact digestion, as can pancreatic disorders such as pancreatitis. Overall, the digestive system is susceptible to a wide range of disorders that can affect its function and health.

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