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That does not always mean the same thing in every case. For some people, squinting helps them to focus their eyes (they need corrective lenses). For others, it is a facial expression that conveys a heightened sense of concern. For others it is an attempt to conceal the direction of their gaze. For others it might be a sign of eye fatigue, or may mean that they are having trouble remaining awake. I once knew someone who had an advanced case of multiple sclerosis, who had trouble holding her eyelids open because her muscles were so weak.

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