Sporozoites are injected into the blood stream of a person by the femal anopheles mosquito. They go straight to the hepatocytes, to form a cystic structure known as a schizont. In 1 - 2 weeks this ruptures releasing hundreds of infective meroizoites in the blood. These merozoites are highly immunogenic, causing the circulating neutrophils and macrophages of the reticulo-endothelial system to release large number of cytokines, and other inflammatory mediators. In particular IL-6 and TNF. These cause the fever with chills and shivering. Some of the merozoites are sequestered by the reticulo-endothelial system. The majority left over infect other red blood cells. Inside the cells they divide, rupture the cell and release another 20 or so merozoites per organism. In this process large number of red blood cells are destroyed resulting in anemia, and hemoglobin in the blood and urine. The red blood cells also become fragile, are destroyed by the spleen, and there is hypersplenism (enlarged spleen). Fragile, infected red blood cells can also lodge in vessels causing damage to that particular organ. This is of major significance in the brain where cerebral malaria can result
Humans for one...
Malaria is a mosquito-borne infectious disease of humans
Chickenpox is caused by a virus, and malaria is caused by a parasite.
Malaria is a infectious disease of humans caused by eukaryotic protists of the genus Plasmodium.see more about malaria CDC information at: cdc.gov/malaria/
the female mosquito transfer malaria by its saliva into blood of human , which causes break down of RBCs
typically via mosquitoes
malaria
Malaria is transmitted among humans by female mosquitoes of the genus Anopheles.
The most deadly protist is Plasmodium falciparum, which causes malaria in humans. It is responsible for the majority of malaria-related deaths worldwide.
Yes. But not exactly in the way humans do.
Humans bitten by female anopheles mosquitoes
West Nile Virus.. Malaria..