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The plague that hit England in 1665 was the last of the many plagues that hit during a 400 year span. As many as 7,000 people per week died in London, while those who could escaped the city and the plague. It is estimated that one of the consequences of the plague was the loss of up to 140,000 people in less than a year. Many businesses closed. Ultimately the Parliament passed the Rebuilding of London Act of 1666, and many of the terrible conditions, such as open sewers running down the middle of the streets, were done away with.

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