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Insulin does not bind to G protein-coupled receptors (GPCRs); instead, it binds to the insulin receptor, which is a receptor tyrosine kinase. Upon binding, the insulin receptor undergoes autophosphorylation and activates its intrinsic kinase activity, leading to the phosphorylation of downstream signaling proteins. This triggers various signaling pathways, including the activation of the PI3K/Akt pathway, which promotes glucose uptake and metabolism. Other pathways, such as the MAPK pathway, can also be activated, influencing cell growth and differentiation.
What else can I help you with?
The outer part of G protein receptor binds and its inner part binds?
The outer part of a G protein-coupled receptor (GPCR) binds to ligands, such as hormones or neurotransmitters, which activates the receptor. The inner part of the receptor interacts with and activates a G protein, initiating downstream signaling cascades within the cell.
Which hormone is water soluble and therefore binds extracellular receptors?
Insulin and epinephrine
How do G protein-coupled receptors (GPCRs) interact with the G protein to initiate cellular signaling pathways?
When a signaling molecule binds to a G protein-coupled receptor (GPCR) on the cell surface, it causes a change in the receptor's shape. This change allows the GPCR to interact with a G protein inside the cell. The G protein then becomes activated and triggers a series of events that ultimately lead to the initiation of cellular signaling pathways.
What is the correct order of events for hormones activating Gs proteins?
Hormone binds to G protein-coupled receptor (GPCR). GPCR undergoes a conformational change and activates the Gs protein. Gs protein activates adenylyl cyclase, leading to the production of cyclic AMP (cAMP). cAMP activates protein kinase A (PKA), initiating a cellular response.
Why is protein hemoglobin different from protein insulin?
They are two different proteins, like the difference between a train and a robot. The difference between one protein and the other is the amino acid sequence that comprises that protein and the molecular bonding that determines its shape. Shape determines function in a protein. If it loses its shape it can't do its job. The shape of insulin and hemoglobin is different so insulin binds with glucose and hemoglobin binds with oxygen.
What happens when a steroid hormonoe binds to a receptor?
acts as a transcription factor and binds to DNA, activating a gene
What happens to the sugar when you inject insulin?
It goes down
What happens if you have a glucokinase deficiency?
You can't produce insulin
What happens in there is over secretion of insulin?
If there is overproduction of insulin then your sugar is low all the time. You will be hypoglycemic all the time.
What happens when calcium binds troponin?
tropomyosin moves out of the groove between the actin molecules.
What happens when a person that does not have diabetes injects insulin?
They could become hypoglycemic, go into insulin shock, coma, and even death.
What happens if insulin gets in your eyes?
Then you can figure everything out, wella.
