The outer part of a G protein-coupled receptor (GPCR) binds to ligands, such as hormones or neurotransmitters, which activates the receptor. The inner part of the receptor interacts with and activates a G protein, initiating downstream signaling cascades within the cell.
Insulin and epinephrine
When a signaling molecule binds to a G protein-coupled receptor (GPCR) on the cell surface, it causes a change in the receptor's shape. This change allows the GPCR to interact with a G protein inside the cell. The G protein then becomes activated and triggers a series of events that ultimately lead to the initiation of cellular signaling pathways.
Hormone binds to G protein-coupled receptor (GPCR). GPCR undergoes a conformational change and activates the Gs protein. Gs protein activates adenylyl cyclase, leading to the production of cyclic AMP (cAMP). cAMP activates protein kinase A (PKA), initiating a cellular response.
acts as a transcription factor and binds to DNA, activating a gene
They are two different proteins, like the difference between a train and a robot. The difference between one protein and the other is the amino acid sequence that comprises that protein and the molecular bonding that determines its shape. Shape determines function in a protein. If it loses its shape it can't do its job. The shape of insulin and hemoglobin is different so insulin binds with glucose and hemoglobin binds with oxygen.
It goes down
You can't produce insulin
If there is overproduction of insulin then your sugar is low all the time. You will be hypoglycemic all the time.
tropomyosin moves out of the groove between the actin molecules.
They could become hypoglycemic, go into insulin shock, coma, and even death.
Then you can figure everything out, wella.