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oxytocin

high estrogen concentration in late pregnancy increases the concentration of oxytocin receptors on the smooth muscle of the uterus (the myometrium), increasing the myometrial sensitivity to oxytocin and this will eventually lead to spontaneous labour

prostoglandins also stimulate uterine contraction

relaxin, secreted by the placenta, and the corpus leuteum of pregnancy, softens the cervix and the pelvic ligaments, making it easier for the baby to pass through the cervix and vagina

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