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Normal Red Blood cells are made up of 2 alpha and 2 beta protein chains.In alpha thalassemia, there's a qualitative decrease in the number of red blood cells (RBC) that have these 2alpha and 2 beta.Since the Alpha protein is made up of 2 genes on Chromosome 16,there are 4 possible alleles.So there's 4 type of Genotypes. 1) A-/AA 2) AA/-- or A-/A- 3) A-/-- 4) --/-- HBH refers to the type of Haemoglobin found in 3) A-/-- in alpha thalassemia whereby 3 out of 4 of the allele is lost due to a deletion mutation on chr 16.

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