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Intracellular Bacteria is bacteria that lives inside of a cell such as a macrophage. If the cell knows the bacteria is living inside of it the cell will destroy it, but some times bacteria can not be detected by the cell, so it lives inside of the cell.

But how does the body destroy intracellular bacteria?

In order for the cell to destroy the intracellular bacteria it needs the assistance of a T-Cell. OK, lets put the cell that contains the intracellular bacteria aside for right now. The T-Cell has previously found a different cell that recognized the virus and destroyed the virus. After the cell destroyed the virus it placed a piece of the virus along with a piece of MHC on the outer wall of itself. The cell is now called a "Presenting Cell". A T-Cell comes along and binds to the presenting cell recognizes that it killed the bacteria and begins to proliferate (divide) into thousands of CD8+ and CD4+ cells. The new CD4+ cells then differentiate or divided in to TH1 or TH2 cells. NOW... as the TH1 cells are moving around our body. The TH1 cells are very good at recognizing cells such as macrophages that have the intracellular bacteria living inside of it. When the TH1 cell find a cell that contains intracellular bacteria, the TH1 cell attaches itself to the cell that contains the intracellular bacteria and reprograms the cell it so it recognizes the intracellular bacteria and then destroys it.

What happens after the TH1 cell reprogrammes the cell that contains the intracellular bacteria?

The reprogramming allows the lysosomes inside of the cell to recognize the bacteria. The cell then forms a Phagosome around the intracellular bacteria. lysosomes inside of the cell attach the Phagosome creating a Phagolysosome. The Phagolysosome is like a bag that contains the intracellular bacteria and destroys the bacteria though lysosomal enzymes and other toxins. The cell then releases the destroyed bacteria as debris.

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