it is the amount of blood available for the heart to pump when the ventricles contract
cardiac output
Preload does not directly influence cardiac contractility, as they are distinct concepts. Preload refers to the degree of stretch of the cardiac muscle fibers at the end of diastole, which affects the volume of blood in the ventricles. While increased preload can enhance the force of contraction through the Frank-Starling mechanism, contractility itself is primarily influenced by factors such as sympathetic nervous system stimulation and circulating hormones. Thus, while preload can affect the overall cardiac output, it does so indirectly through its interaction with contractility.
A change in cardiac output without any change in the heart rate, pulmonary artery wedge pressure (PAWP = equated to preload) or systemic vascular resistance (SVR = afterload) would have to be due to a change in the contractility of the heart. Cardiac output (CO) is roughly equal to stroke volume x heart rate. Stroke volume is related to preload, contractility, and afterload. As you can see, the only variables you have not controlled for is cardiac contractility.
Cardiac contractility is the force of contraction possible for any given length of the cardiac muscle. It is related to the intracellular calcium levels.
Preload refers to the total volume of blood in the ventricles at the end of diastole, just before the heart contracts. It is often described as the degree of stretch of the cardiac muscle fibers, which is influenced by venous return and the filling of the heart. Higher preload generally increases stroke volume due to the Frank-Starling mechanism, where increased stretch leads to a more forceful contraction.
The cardiac cycle is influenced by several factors, including heart rate, preload, afterload, and contractility. Heart rate determines the frequency of cycles, while preload refers to the volume of blood in the ventricles at the end of diastole, affecting stroke volume. Afterload is the resistance the heart must overcome to eject blood, and contractility reflects the strength of the heart's contractions. Additionally, autonomic nervous system activity and hormonal influences can also modulate these factors, impacting the overall efficiency of the cardiac cycle.
John is about to preload his truck with logs.
it decreases blood volume and preload
Preload is caused by decreased blood volume in ventricles. Therefore, decreased preload directly caused by bleeding, polyuria, dehydration.
Nitrate drugs decrease preload by dilating venous blood vessels, which reduces the volume of blood returning to the heart. This venodilation lowers the pressure and volume in the venous system, leading to decreased left ventricular filling. As a result, the heart experiences less stretch and workload during diastole, ultimately reducing the overall preload. This effect helps alleviate symptoms in conditions like heart failure and angina by decreasing cardiac demand.
if you find out tell me what preload is
To adjust the fork preload on your bicycle for optimal performance, use the preload adjustment knob or bolt located on the top of the fork. Turn it clockwise to increase preload for a firmer ride or counterclockwise to decrease preload for a softer ride. Experiment with different settings to find the best balance of comfort and control for your riding style.