Quadriparesis spastika, or spastic quadriparesis, refers to weakness and increased muscle tone affecting all four limbs, often due to neurological conditions like cerebral palsy or multiple sclerosis. Primarna lateralna skleroza, or primary lateral sclerosis (PLS), is a rare neurodegenerative disorder that affects the upper motor neurons, leading to muscle stiffness, weakness, and spasticity. Both conditions can significantly impact mobility and daily functioning, and they may require comprehensive management strategies for symptom relief and support.