prothrombin
Hemophilia is caused by a deficiency of clotting factor VIII (hemophilia A) or clotting factor IX (hemophilia B).
There are the intrinsic and extrinsic pathways in clotting. The intrinsic pathway is initiated when blood comes in contact with damaged endothelium or collagen, and involves clotting factors XII, XI, IX, and VIII. The extrinsic pathway is activated when being exposed to tissue factor from tissue injury or the addition of thromboplastin to blood, and involves clotting factor VII. The two pathways meet at the point of clotting factor X activation to lead the final common pathway. From here, factor X is converted to prothrombin, prothrombin to thrombin, thrombin to fibrinogen, fibrinogen to fibrin, and finally fibrin to fibrin clot. Platelets, activated by thrombin, adhere to the damaged endothelium wall or collagen to form a plug. At the same time, they activate clotting factors VII and X. More platelets are stimulated by fibrin clots, resulting in reinforcing the formed clots.
Haemophilia A - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor VIII Haemophilia B - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor IX Haemophilia C - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor XI -similar to- vonWillebrand's Disorder - an inhibition of clotting caused by a deficiency in a protein called the vonWillebrand's Factor
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The most notable factor affecting how wounds heal is the clotting factor of plasma. If the clotting factor is weak, scars are more likely to form.
In the most common type, Hemophilia A, the person lacks clotting factor VIII. In Hemophilia B, clotting factor IX is lacking.
Serum, it lacks all of the elements needed for clotting. They have been separated out.
The independent variable in a study on blood clotting could be a factor that is manipulated or controlled by the researcher, such as the dosage of a medication, the presence of a certain gene mutation, or the concentration of a specific clotting factor.
The biggest predisposing factor is arteriosclerosis. Atrial fibrillation is another.
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There are three types of hemophilia: A, B, CQueen Victoria was a carrier of hemophilia B.Proteins are blood-clotting factors that hemophiliacs lack.Hemophilia A is Clotting Factor VIII deficiency.Hemophilia B is Clotting Factor IX deficiency.Hemophilia C is Clotting Factor XI deficiency.Hemophiliacs do not bleed more than other people, they simply bleed longer.Hemophilia is NOT contagious.
The main cause of a longer clotting time is the deficiency of the clotting factor in the blood. This is as a result of a damaged platelet in the blood cells.