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Clotting factor causing dvt and pe?
Deep vein thrombosis (DVT) and pulmonary embolism (PE) can be influenced by various clotting factors, but one key factor is Factor V Leiden. This genetic mutation leads to resistance against activated protein C, resulting in an increased tendency for abnormal blood clotting. Other contributing factors include prothrombin gene mutations and deficiencies in natural anticoagulants like protein C, protein S, and antithrombin. These factors can result in a hypercoagulable state, increasing the risk of thrombus formation.
What is the active clotting factor?
The active clotting factor is a protein that plays a crucial role in the blood coagulation process, helping to form a stable blood clot. Each clotting factor is typically designated by a Roman numeral (e.g., Factor I is fibrinogen, Factor II is prothrombin). When activated, these factors undergo biochemical changes that facilitate the conversion of fibrinogen to fibrin, leading to the stabilization of the clot. The interplay between various active clotting factors ensures effective hemostasis and prevents excessive bleeding.
Hemophilia is caused by a defiency of what clotting factor?
Hemophilia is caused by a deficiency of clotting factor VIII (hemophilia A) or clotting factor IX (hemophilia B).
What is blood clotting?
There are the intrinsic and extrinsic pathways in clotting. The intrinsic pathway is initiated when blood comes in contact with damaged endothelium or collagen, and involves clotting factors XII, XI, IX, and VIII. The extrinsic pathway is activated when being exposed to tissue factor from tissue injury or the addition of thromboplastin to blood, and involves clotting factor VII. The two pathways meet at the point of clotting factor X activation to lead the final common pathway. From here, factor X is converted to prothrombin, prothrombin to thrombin, thrombin to fibrinogen, fibrinogen to fibrin, and finally fibrin to fibrin clot. Platelets, activated by thrombin, adhere to the damaged endothelium wall or collagen to form a plug. At the same time, they activate clotting factors VII and X. More platelets are stimulated by fibrin clots, resulting in reinforcing the formed clots.
What are the three types of haemophilias?
Haemophilia A - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor VIII Haemophilia B - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor IX Haemophilia C - an inhibition of clotting caused by a deficiency in a protein called Clotting Factor XI -similar to- vonWillebrand's Disorder - an inhibition of clotting caused by a deficiency in a protein called the vonWillebrand's Factor
What is a clotting factor?
contains nutrients
What changes are seen in clotting time in purpura and hemophilia?
In purpura, which involves bleeding due to vascular abnormalities or platelet issues, the clotting time may remain normal since the primary problem is not with the clotting factors. In hemophilia, a genetic disorder characterized by deficiencies in specific clotting factors (most commonly Factor VIII or IX), the clotting time is prolonged, particularly in tests like the activated partial thromboplastin time (aPTT). This indicates a delayed clotting ability, leading to increased bleeding tendencies.
What factors affect how skin heals?
The most notable factor affecting how wounds heal is the clotting factor of plasma. If the clotting factor is weak, scars are more likely to form.
What are predisposing factors to thrombus formation in the circulation?
The biggest predisposing factor is arteriosclerosis. Atrial fibrillation is another.
What is the protein that hemophiliacs lack?
In the most common type, Hemophilia A, the person lacks clotting factor VIII. In Hemophilia B, clotting factor IX is lacking.
What is the independent variable of blood clotting?
The independent variable in a study on blood clotting could be a factor that is manipulated or controlled by the researcher, such as the dosage of a medication, the presence of a certain gene mutation, or the concentration of a specific clotting factor.
What causes initiation of the blood clotting process?
The initiation of the blood clotting process is primarily triggered by vascular injury, which exposes collagen and tissue factor (TF) to the bloodstream. Platelets adhere to the exposed collagen and become activated, releasing substances that recruit more platelets to the site. This forms a temporary platelet plug, while the intrinsic and extrinsic pathways of the coagulation cascade are activated, ultimately leading to the formation of fibrin strands that stabilize the clot.
