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The humerus, or upper arm bone, has seven letters. It is the largest, and therefore the strongest, such bone. (The femur, or thighbone, only has five letters.)

If this is a riddle, it's possible that the answer was intended to be the cranium; but technically the cranium is a collection of eight separate bony plates surrounding the brain, and not a single bone in and of itself. Likewise with the jawbone, which is actually three bones: the mandible and maxillae.

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