V09.1 Infection with microorganisms resistant to cephalosproins and other B-lactam antibiotics.
V09.1, however, would not be your primary diagnosis code. As it is stated in the ICD-9-CM, Category V09 is intended for use as an additional code for infections conditions classified elsewhere to indicate the presence of a drug-resistance of the infectious organism.
Per Wikipedia:
ESBL, or Extended Spectrum Beta Lactamase, are bacteria that produce enzymes that exhibit resistance to extended-spectrum (third generation) Cephalosporins (i.e.Ceftazidime, Cefotaxime, and Ceftriaxone) and Monobactams (i.e.. Aztreonam) but do not affect Cephamycins (eg. Cefoxitin and Cefotetan) or Carbapenems (i.e. Meropenem or Imipenem).
The most common ESBL-producing bacteria are Escherichia coli (E. coli), Klebsiella pneumoniae, and Klebsiella oxytoca. You'll need to dig further in the patients chart to see which of these is the culprit, and code that as your primary diagnosis, followed by V09.1.
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A beta-lactamase is an enzyme produced by certain bacteria, which is responsible for their resistance to beta-lactam antibiotics.
Ampicillin class C beta lactamase
Co-amoxiclav is an approved British name for the combination antibiotic containing compounds such as amoxicillin trihydrate, a beta-lactam antibiotic, with potassium clavulanate, and a beta-lactamase inhibitor. The combination yields an antibiotic with an increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce beta-lactamase.
Clavulanic acid is a potent inhibitor of beta-lactamase enzymes. It is often combined with certain antibiotics like amoxicillin to enhance their effectiveness by protecting them from degradation by beta-lactamase enzymes.
Beta-lactamase inhibitors, protect the penicillin from bacterial enzymes that may destroy it before it can do its work.
Some bacteria produce beta lactamase enzyme, this enzyme will break the beta lactam ring structure of certain antibiotics (penicillin, cephalexin for example) rendering them ineffective against the infection. If you add a beta lactamase inhibitor to a beta lactam antibiotic (i.e clavulanaic acid added to amoxicillin) it decreases the potential of the bacteria to inactivate the antibiotic.
Beta-lactamase-positive bacteria produce an enzyme called beta-lactamase which can inactivate beta-lactam antibiotics, such as penicillin, by breaking down the beta-lactam ring in the antibiotic molecule. This makes the bacteria resistant to beta-lactam antibiotics.
ESBL (Extended-Spectrum Beta-Lactamase) is not contagious in the traditional sense, as it refers to a type of antibiotic-resistant bacteria rather than a disease. However, the bacteria that produce ESBL can spread through direct contact with contaminated surfaces, hands, or bodily fluids. Good hygiene practices, such as handwashing, can help prevent its transmission in healthcare settings and the community.
Augmentin is a combination antibiotic that contains amoxicillin and clavulanate potassium. Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Clavulanate potassium acts as a beta-lactamase inhibitor, protecting amoxicillin from degradation by certain bacteria that produce beta-lactamase enzymes, thereby enhancing the efficacy of the antibiotic against resistant strains. Together, they broaden the spectrum of activity against various bacterial infections.
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If you are wondering what is the name of a drug that contains amoxicillin - one would be Augmentin. This is made of amoxicillin and clavulanate. Clavulanate is what is referred to as a 'beta lactamase inhibitor' and this allows amoxicillin to be effective against drug-resistant bacteria that produce beta lactamase. Words ending in -ase are generally enzymes that are going to break something down. The penicillin family of antibiotics are called 'beta lactams' due to their structure. Some bacteria have developed beta lactamase in order to break down these antibiotics, thereby becoming a drug-resistant bacteria.