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Sickle-cell Anemia, or Sickle-cell Disease, is a disease which is caused by a mutation in the animo acid sequence of the red blood cells.

The type of mutation occurs during the transcription of messenger RNA (e.g. GTC becomes CCG instead of CAG ). This change causes the mRNA to translate into a different amino acid (e.g. Valine instead of Glutamate ).

In this disease, the changes start in amino acids, the primary structure of proteins, thus changing all the higher protein structures. The red blood cells then will have a different shape, like a sickle.

These sickle shaped red blood cells will nor function normally. Thier shape disables them from flowing easily in the blood vessels, which might lead to further complications. Also, their life span is shorter than the normal cells, hence causing Anemia.

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A chronic, inherited blood disorder characterized by crescent-shaped red blood cells. It occurs primarily in people of African descent, and produces symptoms including episodic pain in the joints, fever, leg ulcers, and jaundice.
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14y ago

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