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Small fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, or shooting pain. The variety of diseases that may result in a small fiber neuropathy, include Diabetes and other glucose dysregulation syndromes, thyroid dysfunction, sarcoidosis, vitamin B12 deficiency, HIV, neurotoxic medications, celiac disease, paraneoplastic syndromes, and paraproteinemias. Despite extensive diagnostic evaluation, majority with small fiber neuropathy ultimately may be given a diagnosis of chronic pain.

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