The classical complement pathway is a group of proteins that arrange the antibody response when you are sick. So basically they will spring into action when something is not right in your body.
Factor B is the key complement protein that helps activate the alternative pathway of complement activation. It forms a complex with Factor D and is cleaved by Factor D to produce the active fragment, which leads to further activation of the alternative pathway.
Complement is part of the innate immune system (one you are born with). It consists of small protein molecules that circulate in the blood stream. Complement has three pathways, The classic pathway; The alternative pathway; and the lectin pathway. In the classical pathway, complement is activated by triggers such as the binding of an antigen to an antibody. In the alternative pathway, Complement is part of the natural immune system and complement assist in the opsonization, or the marking of an antigen to be destroyed by a phagocyte. This like the antigen has been marked with black marker so that a killer cell (phagocyte-cell eater) can find it to eat it. Finally the lectin pathway, which is similar to the classical pathway in terms of structure but this pathway starts with lectin or ficolin binding to sugars. After activation complement can trigger any number of events such as opsonization, chemotaxis, inflammation, and lysis (breaking) of cells.
mannose on the parasite
activation of the complement via the alternative pathway
C2a
It does not rely on activation by antibodies.
The alternative pathway complement is a part of the immune system that helps to identify and destroy harmful pathogens like bacteria. It works by activating proteins that form a complex chain reaction, leading to the destruction of the pathogen. This pathway is important for the body's defense against infections.
The alternative pathway of complement activation is a part of the immune system that helps to identify and destroy harmful pathogens. It is a rapid and efficient process that can be activated without the need for specific antibodies. This pathway plays a crucial role in the early stages of the immune response by enhancing inflammation, promoting phagocytosis, and directly killing pathogens.
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Viral reproduction. See more in the related questions below.
The complement system is a series of about 20 proteins that are involved in a cascade effect during an immune response. Complement is generally divided up into 3 pathways: classical, lectin, alternate. The classical pathway involves a complement protein binding to an antigen-antibody complex (and thus its role in adaptive immunity). Whereas in the alternate pathway, complement (C3) binds directly to the foreign cell( usaully bacteria). Thus its repsonse is non specific and therefore is also part of the innate imune system.
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