Sometimes problems occur with a blood transfusion, but that is supposed to be rare. Some people can have an allergic reaction to the transfusion.
This is a point where continual decline will occur. But, it is not necessarily where problems will now begin.
A transfusion reaction is typically an acute hypersensitivity reaction to foreign red blood cells, which can occur immediately or within a few hours of the transfusion. Subacute hypersensitivity reactions usually take days to develop after exposure to the antigen, unlike the immediate onset of symptoms seen in transfusion reactions.
FDA guidelines require a temporary deferral of one year from date of transfusion for potential donors who have received blood products. This is to minimize the possibility of transfusion-transmitted diseases entering the blood supply. Though unlikely, there is a risk of transfusion-acquired infections with all blood component use. The one year deferral allows any potential disease to be present long enough to be detected by FDA-mandated screening tests.
the transfusion reaction doesn't occur the first time an Rh+ patient is exposed to Rh- blood because the Rh+ patients body hasn't created the antibodies needed to attack the Rh- blood that it comes in contact with. the second time the Rh+ patients body comes in contact with Rh- blood, it will have the antibodies necessary to fight against Rh- blood.
Drops significantly.
If this happens, antibodies that the patient already has in his or her blood will attack the donor red blood cells and destroy them. This could cause fever, chills, chest or back pain.
The person with Rh- blood will begin to make antibodies against Rh+ upon exposure. This may not occur with the first transfusion - but it is still not recommended to give an Rh- person Rh+ blood.
Clumping of blood cells, known as agglutination, can occur due to immune responses such as the production of antibodies against antigens present on the surface of the blood cells. This can happen in conditions like transfusion reactions or autoimmune disorders where the immune system mistakenly targets the body's own blood cells. Agglutination can lead to blockage of blood vessels and impaired circulation, potentially resulting in organ damage or other serious consequences.
The person's body will immediately begin destroying the B blood cells, causing shock and possibly even death. People carry naturally occurring antibodies to A or B antigens if they are not that type, which react strongly with transfused blood to destroy it.
Describe what happen to the body from a injure do to blood loss occur
DefinitionA hemolytic transfusion reaction is a serious problem that occurs after a patient receives a transfusion of blood. The red blood cells that were given to the patient are destroyed by the patient's own immune system.Alternative NamesBlood transfusion reactionCauses, incidence, and risk factorsBlood is classified into different blood types called A, B, AB, and O.The immune system normally can tell its own blood cells from blood cells from another person. If other blood cells enter your body, your immune system may make antibodies again them. These antibodies will work to destroy the blood cells that the body does not recognize. For example, a person with type A blood makes antibodies against type B blood cells.Another way blood cells may be classified is by Rh factors. People who have Rh factors in their blood are called "Rh positive." People without these factors are called "Rh negative." Rh negative people form antibodies against Rh factor if they receive Rh positive blood.There are also other factors to identify blood cells, in addition to ABO and Rh.Blood that you receive in a transfusion must be compatible. Being compatible means that your body will not form antibodies against the blood you receive. Blood transfusion between compatible groups (such as O+ to O+) usually causes no problem. Blood transfusion between incompatible groups (such as A+ to O-) causes an immune response. This can lead to a very serious transfusion reaction. The immune system attacks the donated blood cells, causing them to burst.Today, all blood is carefully screened. Modern lab methods and many checks have helped make these transfusion reactions very rare.SymptomsBloody urineChillsFainting or dizzinessFeverFlank pain or back painRashSymptoms of transfusion reaction usually appear during or right after the transfusion. Sometimes, they may develop after several days (delayed reaction).Signs and testsThis disease may change the results of these tests:BilirubinCBCCoombs' test, directCoombs' test, indirectFibrin degradation productsHaptoglobinHematocritHemoglobinRBC countSerum creatinineSerum hemoglobinUrinalysisTreatmentTherapy can prevent or treat the severe effects of a hemolytic transfusion reaction. If symptoms occur during the transfusion, the transfusion is stopped immediately. Blood samples from the person getting the transfusion and from the donor may be tested to tell whether symptoms are being caused by a transfusion reaction.Mild symptoms may be treated with the following:Antihistamine drugs (such as diphenhydramine) can treat itching and rash.The pain reliever, acetaminophen can reduce fever and discomfort.Corticosteroids (such as prednisone or dexamethasone) can reduce the immune response.Fluids given through a vein (intravenous) and other medications may be used to treat or prevent kidney failure and shock.Expectations (prognosis)The outcome depends on the severity of the reaction. The disorder may disappear without problems. Or, it may be severe and life threatening.ComplicationsAcute kidney failureAnemiaDiscomfortLung dysfunctionShockCalling your health care providerTell your health care provider if you are having a blood transfusion and you have had a reaction before.PreventionDonated blood is put into ABO and Rh groups to reduce the risk of transfusion reaction.Before a transfusion, patient and donor blood is tested (crossmatched) to see if it is compatible. A small amount of donor blood is mixed with a small amount of patient blood. The mixture is checked under a microscope for signs of antibody reaction.Before the transfusion is given, the health care provider will usually check again to make sure you are receiving the right unit of blood.ReferencesGoodnough L. Transfusion medicine. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 183.