The tiny air pockets in the lungs can break down.
The blood vessels in the lungs can become clogged.
The outer lining of the lungs can stiffen.
Fluid can build up outside the lungs, reducing the capacity to expand.
Fluid can accumulate inside the lungs.
Foreign particles can accumulate in the lungs, preventing exchange of oxygen and and carbon dioxide.
Lung tissue can develop tumors.
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you can have lung cancer or farmers lungs if you breathe in to much hay without wearing a mask and never smoke its very very bad for you that's probaly the number one reason to have lung cancer.