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Q: When the level of ADH increases does less water get reabsorbed by the nephron and collecting duct?
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Antidiuretic Hormone is made in hypothalamus (posterior pituitary gland). Stimulated by dehydration and increased blood osmosis. It acts on the collecting duct of nephron to increase amount of aquaporins, thus increasing water permeability. When increased water is reabsorbed, blood osmolarity decreases. Therefore the urine becomes more concentrated.


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How does the hormone ADH control urine volume and concentration?

adh controls the volume of urine by regulating the amount of water absorbed into the convoluted tubules. . At some point ,change in blood level activates the osmoreceptors in the hypothalamus which in turn activates the release of antidiuretic hormone(ADH). ADH is released into the blood stream, then it travels to the kidney's collecting ducts whilst in the kidney, ADH increase the number of water channels in the membrane of the collecting duct cells ADH binds to the cell membrane receptors to activate phosphorylase enzyme. This causes the vesicle containing aquaporins to fuse with the membrane. Therefore water is reabsorbed from the filtrated to produce concentrated urine which passes into the tubules, collects in the renal pelvis and flows through the ureters into the urinary bladder. The reabsorbed water increases the water potential of the blood, osmoreceptors are no longer activated and so ADH production stops. This is an example of negative feedback response consequently, their removal is accompanied by an unavoidable water loss