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From the time a cold virus enters the nose, it takes 8-12 hours for the viral reproductive cycle to be completed and for new cold virus to be released in nasal secretions. This interval is called the incubation period. Cold symptoms can also begin shortly after virus is first produced in the nose (10-12 hours). The time from the beginning of the infection to the peak of symptoms is typically 36-72 hours.

So about 10-12 hours after the virus first enters the nose is when the infected person will begin to notice symptoms; the worst symptoms will be around 36-72 hours after infection.

Sources: http://www.commoncold.org/undrstn3.htm

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