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Spanish explorers established the first towns of New Spain primarily in present-day Mexico. The most notable early settlement was Mexico City, built on the ruins of the Aztec capital, Tenochtitlán, in 1521. Other significant towns included Veracruz and Puebla, which served as important centers for trade, administration, and the spread of Spanish culture and religion. These towns laid the foundation for further exploration and colonization throughout the Americas.

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