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What happens when parietal cells shrink?
When these parietal cells shrink in size (atrophy), they produce less and less intrinsic factor
What the importance of intrinsic factor?
Intrinsic factor is glycoprotein that is produced by the parietal cells of the stomach.
How pernicious anemia cause achlorhydria?
pernicious anemia is a vitamin B12 deficiency. Vitamin B12 requires Intrinsic Factor to be reabsorbed by the ileum. Intrinsic Factor is produced by parietal cells in stomach. If there is some damage or manipulation of parietal cells, which also produce HCl, there will be less of both intrinsic factor causing B12 deficiency and HCl causing achlorhydria.
Aids in absorption of vitamin b12?
Intrinsic factor, a protein produced in the stomach, helps in the absorption of vitamin B12. This vitamin is crucial for red blood cell formation and neurological function. Absorption of vitamin B12 occurs in the small intestine, where it binds to intrinsic factor for transport into the bloodstream.
Is hydrochloric acid necessary to produce the intrinsic factor for cobalamin?
No, hydrochloric acid (HCl) is not necessary to produce the intrinsic factor for cobalamin. HCl is needed along with gastric enzymes to free Cobalamin (B12) from its polypeptide linkages in food. The intrinsic factor involved with the digestion and absorption of Cobalamin (B12) is a glycoprotein.
How stomach helps in erythropoiesis?
parietal cells which can be found in gastric gland of stomach secretes intrinsic factor, which is a type of glycoprotein. this intrinsic factor, together with vitamin B12 is required for effective absorption of iron in small intestine. iron is required in erythropoiesis to produce haemoglobin. if iron absorption is low, RBC production will be affected. in summary, stomach helps in RBC production by producing intrinsic cells required in iron absorption.
Which cells of the stomach secretes hydrochloride acid and intrinsic factor?
The parietal cells of the stomach are responsible for secreting hydrochloric acid, while the chief cells secrete intrinsic factor. These two secretions are important for the digestion of food and absorption of nutrients in the stomach and intestine.
What is important function of the intrinsic factor found in the stomach?
the b12 intrinsic factor produced by the parietal cells in the stomach (parietal cells also produce HCL, the acid that dissolves food and converts pesinogen (secreted by the chief cells). B12 is necessary for carbohydrate, protein and fat to be used by the boy but most importantly b12 is necessary for all cells in the body (especially red blood cells) to work properly; if deficient in the body the person may develop pernicious anemia (due to the excessive destruction of immature blood cells or the lack of their production due to a lack of vitamin b12) as well as other problems such as problems with the nervous system sue to the fact that b12 is used to cover nerve cells thus the lack of vitamin b12 can also get to the brain and in kill the person. The intrinsic factor secreted by the stomach's parietal cells is used to absorb vitamin b12 as the body cannot absorb it on its own. As a result the intrinsic factor is essential for life as there will be vitamin vb12 deficiency if there is no intrinsic factor to help the boy absorb it. Another important fact is that vitamin b12 is absorbed( with the help of the intrinsic factor) by cubulin receptors in the ileum of the small intestine.
Where the parietal cells of the stomach is necessary for vitamin B12 absorption?
Parietal cells in the stomach are essential for vitamin B12 absorption because they produce intrinsic factor, a glycoprotein crucial for the absorption of vitamin B12 in the small intestine. When food enters the stomach, vitamin B12 binds to intrinsic factor, forming a complex that protects it from digestion. This complex is then absorbed in the ileum, the final part of the small intestine. Without intrinsic factor, vitamin B12 cannot be effectively absorbed, leading to potential deficiencies.
What is the difference between parietal cells and chief cells?
Parietal cells are stomach cells that produce hydrochloric acid and intrinsic factor, while chief cells secrete pepsinogen, which is later activated into pepsin to help with protein digestion. Parietal cells are involved in acid production, while chief cells assist in protein digestion.
What is perniciousness?
This is anaemia (lowered blood haemoglobin) due to a lack of vitamin B12 absorbed from the intestinal tract, due to a lack of intrinsic factor usually. This can be due to auto antibodies against the cells that produce intrinsic factor, stomach ulcers crowding out the cells that produce intrinsic factor, a hereditary lack of intrinsic factor or the after effects of surgery, illness or fish tapeworm. This gives a macrocytic anaemia. Pernicious anemia is an autoimmune disease that renders the person unable to absorb sufficient Vitamin B-12. Eventually the person becomes Vitamin B-12 deficient and must be treated. Prior to the availability of treatment persons died from the disease, hence the name pernicious. It is critical that treatment be obtained as soon as possible. You can find more information at the following website: www.pernicious-anaemia-society.org
What stomach secretion is necessary for normal hemoglobin Production in RBC's?
Intrinsic factor is secreted by the parietal cells and is critical for absorption of B12. When the body attacks the parietal cells b12 deficiency results which is called "pernicious anemia."
