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Individuals would have the greatest difficulty preventing diseases that are primarily influenced by genetic factors, such as certain cancers (like breast or colon cancer) and hereditary conditions (like cystic fibrosis). These diseases often develop due to inherited mutations that individuals have no control over. Additionally, complex diseases like Diabetes and Heart disease, influenced by both genetics and lifestyle factors, can also pose significant prevention challenges. Ultimately, while lifestyle choices play a role, inherent genetic predispositions can make prevention difficult.

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