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The primary affected organ system with Type 2 Diabetes is the endocrine system. The pancreas, which is responsible for insulin production, is part of this system.

However, with the way the body works, a problem with the endocrine system can greatly affect other organ systems.

For example, a diabetic with poor glucose control that routinely has high glucose readings can have problems with their circulatory system. For example, since it's easier to picture, imagine a sugar cube instead of just a single grain of sugar. It's not a smooth surface, in fact it's rather rough around the edges. Excess sugar flowing through your bloodstream on a microscopic level looks the same with its rough edges. The sugar can scrape the walls of arteries, as it scrapes, the artery heals the micro-cut by scarring over, and when it scars, it hardens. Enough of this over time can create the condtion known as Arteriosclerosis.

One way to look at it is in a way, liken it to AIDS. An AIDS sufferer doesn't actually die from AIDS itself, they die from complications from it, from things like pneumonia because their body can't fight it off.

Now granted people DO die from diabetes (it is possible to die from a Diabetic Coma or from hypoglycemia if you have hypoglycemic unawareness), but the majority of health problems diabetics have are a result of another organ system that the diabetes has affected, such as the circulatory system, from Heart disease and so on.

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