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The tissue of the heart is composed of three major layers:

The outer most is the Epicardium. "Epi" refers to "outside"

The inner most layer is the Endocardium. "Endo" refering to "inside"

The layer in between is called the Myocardium. It is the thickest layer and is composed of cardiac muscle. Thus its name, as "myo" is a prefix meaning "muscle".

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