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This is because their is no receptor to facilitate IgM on the placenta. IgM is too big is a common, and wrong misconception.

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13y ago

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What are the first antibodies produced by a newborn?

The first antibodies produced by a newborn are primarily Immunoglobulin M (IgM) antibodies. These antibodies are typically produced in response to infections and are essential for the initial immune response. Additionally, newborns receive Immunoglobulin G (IgG) antibodies through the placenta during pregnancy, providing passive immunity. However, the active production of IgM begins shortly after birth as the infant's immune system starts to develop.


Why IgM is not transferred from mother to child?

IgM is a large antibody that cannot efficiently cross the placenta due to its size and structure. In contrast, IgG is the predominant immunoglobulin transferred from mother to child, as it can easily pass through the placental barrier. This transfer is crucial for providing the newborn with passive immunity, protecting them against infections in the early months of life. IgM remains primarily in the bloodstream, where it functions in the immune response but does not provide this type of maternal immunity to the fetus.


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Import General Manifest (IGM) IGM will be filed by Liner or agent of Liner through on-line system (I don't know what they call it, IceGate or some other system) IGM declaration should be done with in 24 hours of arrival of the ship/vessel. Amendment of IGM is possible, with proper reasons to Customs


Why immunoglobulin G alone can cross placenta?

IgG is an immunoglobluin monomer, meaning that it is one immunoglobulin that is small enough to cross the placenta. An example would be the Rh antibody that causes isoimmunization between Rh negative mothers and Rh positive fetuses. In constrast, ABO blood group immunoglobulins are IgM which is a pentamer, meaning it is composed of 5 immunoglobulins and is too large to cross the placenta.


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What is an IgM antibody?

IgM is produced upon initial exposure to an antigen. For example, when a person receives the first tetanus vaccination, antitetanus antibodies of the IgM class are produced 10 to 14 days later. IgM is abundant in the blood.


What is CMV AB IGM?

CMV AB IGM refers to the presence of IgM antibodies against cytomegalovirus (CMV). IgM antibodies are produced early in the immune response to a current or recent CMV infection. Detection of CMV IgM antibodies can aid in diagnosing an active CMV infection.


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CMV IgM is a lab test that detects IgM for cytomegalovirus (CMV), usually in blood. IgM usually indicates a recent or current infection; in the case of CMV, it may also indicate reactivation of an old, latent infection.


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What is IGM?

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What Ig is a pentamer?

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