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Carcinogens are difficult for toxicologists to identify due to their complex mechanisms of action, which can involve genetic, environmental, and lifestyle factors that vary greatly among individuals. Additionally, the long latency periods between exposure and the onset of cancer can obscure direct cause-and-effect relationships, making it challenging to establish clear links. The diversity of cancer types and their multifactorial nature further complicate the identification process, as many substances may only pose a risk under specific conditions or in combination with other factors.

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