Not sure if this is right but could it be because the blood cell does not contain enough oxygen for the parasite to survive?
People with sickle cell disease, or who carry sickle cell trait, are said to be resistant to malaria.
Malaria is common in topical ad subtropical zones. The malaria has selected the people with sickle cell anaemia. Although person with sickle cell anemia can have malaria, the carrier, or the person with sickle cell trait is resistant to malaria.
Sickle cell anemia comes as the result of having two sickle cell chromosomes. One sickle cell chromosome makes people resistant to malaria. Unfortunately when people have two sickle cell chromosomes they can get sickle cell anemia. That makes it difficult for their blood to carry oxygen and under certain conditions makes their blood clump. The disease can be deadly. Drugs can help. It probably makes that person resistant to malaria. The sickle cell trait evolved in various places around the world where malaria is common such as Africa and Greece.
the sickle trait possess a resistance to the infection of malaria.
They can not contract malaria.
Individual homozygous for the sickle cell anemia allele
Individuals with the Ss genotype are resistant to malaria because the presence of the sickle cell trait (S gene) alters the shape of red blood cells, making it difficult for the malaria parasite to infect and replicate within the cells. This in turn reduces the severity of malaria symptoms and provides a natural defense mechanism against the disease.
Since people with the sickle cell allele trait are resistent to malaria, if malaria were eliminated there would be no change in the frequncy of sickle cell allele. This is because the presense of malaria does not have an affect on patients with the sickle cell allele trait.
Sickle cell anemia cause red blood cells to be shaped like sickles. malaria can't enter these cells which gives the person an immunity to malaria.
by mosqitos
Sickle cell anemia comes as the result of having two sickle cell chromosomes. One sickle cell chromosome makes people resistant to malaria. Unfortunately when people have two sickle cell chromosomes they can get sickle cell anemia. That makes it difficult for their blood to carry oxygen and under certain conditions makes their blood clump. The disease can be deadly. Drugs can help. It probably makes that person resistant to malaria. The sickle cell trait evolved in various places around the world where malaria is common such as Africa and Greece.
Sickle cell anemia is an autosomal recessive disease. Carriers have sickle cell trait, which confers resistance to malaria.