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In the case of protein digesting enzymes, known as endopeptidases, such as those secreted in the stomach (pespin), it is obvious. If they were secreted active they would digest the glands which secrete the enzymes themselves (gastric glands).

Instead they must be secreted in an inactive form, which once in the stomach and exposed to HCl acid and other pepsin enzymes the pepsinogen activates and begins digesting protein.

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