Signal receptors are often over-expressed in cancer because they play a crucial role in regulating cell growth, survival, and differentiation. Cancer cells frequently hijack these signaling pathways to promote uncontrolled proliferation and evade apoptosis. Additionally, the tumor microenvironment can stimulate the expression of these receptors, further enhancing cancer cell survival and resistance to therapies. This over-expression can contribute to the aggressive nature of tumors and their ability to metastasize.
Oncogenes are genes that C) can signal cells to reproduce uncontrollably. They typically arise from mutated proto-oncogenes, which normally regulate cell growth and division. When these genes become activated or overexpressed, they can lead to cancer development by promoting excessive cell proliferation.
Hydrophobic signal molecules can interact with intracellular receptors, such as nuclear receptors and cytoplasmic receptors. These receptors are typically located inside the cell and can directly bind the hydrophobic signal molecules, leading to changes in gene expression and cellular function.
dissolved odorants bind to the receptors in the cilium membranes.
receptors
The brain itself does not have pain receptors because it does not feel pain. Pain receptors are located in other parts of the body to signal potential harm or damage to the brain.
One of the most common molecules of the cell that transmit information from outside to inside are transmembrane receptors. Typically, a ligand will bind to to exterior portion and trigger receptor activation, leading to downstream signaling within the cell.
Second messengers, such as cyclic AMP and calcium ions, are commonly utilized by enzymatic receptors and G-protein-coupled receptors to carry the signal molecule's message into the target cell. These second messengers help amplify and propagate the initial signal, leading to various cellular responses.
Stretch receptors in the bladder wall are activated when the bladder fills with urine or liquid. These receptors signal the brain to indicate the fullness of the bladder, triggering the urge to urinate.
Cells receive signals through receptors located on the cell membrane
When receptors are activated, they generate a signal that triggers a cellular response. This signal is typically transmitted through a series of molecular pathways within the cell, leading to a specific physiological outcome such as gene expression, muscle contraction, or cell division.
A tissue is considered a target tissue when it has specific receptors for a particular hormone or chemical signal. These receptors allow the tissue to respond to the signal by initiating specific biological responses. Target tissues are often the primary sites where the hormone or signal exerts its effects in the body.
Dendrites of a postsynaptic nerve contain receptors for neurotransmitters released by the presynaptic neuron. These receptors detect and respond to the neurotransmitters by initiating an electrical signal that travels towards the cell body. This signal determines whether the neuron will fire an action potential.