Yes. When hemoglobin is broken down into heme and globin, the heme sends bilirubin to your liver. If your liver isn't functioning properly it won't be able to secrete it into your intestines.
When the liver is damaged as with hepatitis it is no longer able to metabolize the bilirubin in the blood and causes jaundice which is a yellowing of the whites of the eyes and skin.
Indirect bilirubin is a type of bilirubin that is unconjugated, meaning it is not bound to other compounds in the liver. It is produced when red blood cells break down and is then processed by the liver to be converted into direct bilirubin for excretion. High levels of indirect bilirubin in the blood may indicate liver or gallbladder issues.
The presence of bilirubin can be confirmed through blood tests such as a total bilirubin test or a direct bilirubin test. These tests measure levels of bilirubin in the blood to assess liver function and diagnose conditions such as jaundice or liver disease.
The liver. The liver is damaged. The yellow color of the skin indicates that the liver can no longer conjugate bilirubin properly.
The liver is primarily responsible for detoxifying red blood cells. It filters out old or damaged blood cells and helps to break down hemoglobin from those cells into bilirubin, which is then excreted in bile.
A bilirubin test is used to measure the levels of bilirubin in the blood, which helps in diagnosing conditions related to liver function and red blood cell breakdown. High levels of bilirubin can indicate issues such as liver disease, hemolytic anemia, or blockage of bile ducts.
From the glossary of medical terms the answer is: BILIRUBIN
Total bilirubin is a measure of the bilirubin levels in the blood, which is a yellow compound produced during the breakdown of red blood cells. It consists of two fractions: unconjugated (indirect) bilirubin, which is not water-soluble and is processed by the liver, and conjugated (direct) bilirubin, which is water-soluble and excreted in bile. Elevated levels of total bilirubin can indicate liver dysfunction, bile duct obstruction, or hemolysis. Testing total bilirubin is often part of a liver function panel to assess liver health.
Damage to the liver or the Kidneys may cause a build up of Bilirubin.
The liver is the organ most affected when bilirubin levels are high in the body. The liver is responsible for processing bilirubin, a waste product of the breakdown of red blood cells, and eliminating it from the body. High levels of bilirubin can indicate liver dysfunction or other underlying health problems.
Bilirubin can be measured through a blood test to assess liver function and detect liver diseases such as hepatitis, cirrhosis, or obstruction of the bile ducts. Abnormal levels of bilirubin in the blood can indicate liver problems or issues with red blood cell breakdown.
In hepatic jaundice, direct bilirubin levels increase due to impaired liver function, which affects the liver's ability to conjugate and excrete bilirubin. When liver cells are damaged or inflamed, such as in hepatitis or cirrhosis, they may not effectively process unconjugated bilirubin into its conjugated form. Consequently, both direct (conjugated) and indirect (unconjugated) bilirubin can accumulate in the bloodstream, leading to jaundice. The increase in direct bilirubin specifically indicates that the liver is attempting to process bilirubin but is unable to eliminate it adequately.