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Ceruloplasmin is a copper-containing protein. This article discusses the test to measure the level of the protein in the clear liquid part of the blood (serum).
How the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
How to prepare for the testNo fasting or other preparation is usually needed.
How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performedYour health care provider may order this test if you have signs or symptoms of a copper metabolism or copper storage disorder.
Normal ValuesNormal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
What abnormal results meanLower-than-normal ceruloplasmin levels may indicate:
- Menkes' syndrome (Menkes' kinky hair syndrome) -- very rare
- Wilson's copper storage disease (rare)
Greater-than-normal ceruloplasmin levels may indicate:
- Pregnancy
- Lymphoma
- Acute and chronicinfections
- Rheumatoid arthritis
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Kowdley KV. Inherited and metabolic hepatic disorders. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 154.
What else can I help you with?
Which carries copper in plasma proteins?
Copper in plasma is mainly carried by ceruloplasmin, a copper-binding protein. Ceruloplasmin promotes copper transport in the blood and helps regulate copper levels in the body.
What is Ceruloplasmin used for in the body?
Ceruloplasmin is an enzyme that is important in the human body. It is synthesized by the liver. It carries much copper and has a major role in iron metabolism.
What is an aceruloplasminemia?
An aceruloplasminemia is a lack of ceruloplasmin in the blood, or the disorder associated with it.
What is the dangerous of ceruloplasmin?
Ceruloplasmin itself is not inherently dangerous; rather, it is a copper-carrying protein in the blood that plays a crucial role in iron metabolism and antioxidant defense. However, abnormal levels of ceruloplasmin can indicate health issues. Low levels may be associated with Wilson's disease, leading to copper accumulation and toxicity, while high levels can occur in conditions like inflammation and certain cancers. Monitoring ceruloplasmin levels is important for diagnosing and managing these conditions.
What is the ceruloplasmin?
Ceruloplasmin is a copper-carrying protein found in blood that plays a role in iron metabolism and antioxidant defense. It helps regulate the levels of copper in the body and is involved in the formation of neurotransmitters and connective tissue. Abnormal levels of ceruloplasmin can indicate certain health conditions, such as Wilson's disease.
Which blood protein transports copper?
The blood protein that transports copper is ceruloplasmin. Ceruloplasmin helps regulate copper levels in the body by binding to copper and transporting it to where it is needed, such as to the liver for storage or to cells for use in various biochemical processes.
Why do birth control hormones make plasma green in blood donors?
Birth control pills (BCPs) mimic pregnancy during which the lelvel of a copper containing protein ceruloplasmin is elevated. Just like oxidized copper turns green (verdigris= Copper ++) think statue of liberty!
What is Wilson's Disease?
it is a rare diorder of abnormal copper metabolism and is characterised by: hepatolenticular degeneration. copper get deposited in abnormal amounts in liver and lenticular nucleus of brain leading to necrosis of liver and brain. low level of copper and ceruloplasmin in plasma with increased excretion of copper in urine, copper deposition in kidneys causes renal damage. causes: failure in the synthesis of ceruloplasmin. excess copper in plasma. reduced intestinal excretion of copper. treatment: penicillamine.
Are there Genetic Diseases similar to Wilson disease?
I'm not a doctor. I don't know that the diagnoses of lyme and wilson's would normally overlap, but my husband is an atypical case. He has late stage neurological lyme disease and the doctors are testing him for Wilson's disease as a differential diagnosis. I think mostly to rule it out. HisLooking into Wilson's because:My husband is in his 20s,has dystonia and myoclonic jerks,as well as emotional and cognitive changes.Slightly elevated liver enzymeshis ceruloplasmin test came back in range, but on the very low end of normalHe doesn't recall a tickbite and never noticed a bullseye rash but has tested positive for lyme.
What has the author Mary Winchester Abbott written?
Mary Winchester Abbott has written books such as "Behind the Mask: The Life of Vita Sackville-West" and "A Russian Novel." She is known for her biographies of notable figures and her exploration of Russian art and culture.
What are (at least) 5 properties of water?
(1) Plasma proteins are large molecules with molecular weights ranging mostly from 50,000 to 300,000 Daltons. (2) With the notable exception of albumin, nearly all plasma proteins are Glycoproteins, containing oligosaccharides. The oligosaccharide chains are responsible for certain properties of plasma proteins like solubility, viscosity, charge, denaturation etc. (3) like most other proteins, their charged residues tend to be located on the surface. (4) Many plasma proteins exhibit polymorphism. Polymorphism is a Mendelian trait that exists in the population in at least two phenotypes, neither of which is rare. Plasma proteins showing polymorphism are haptoglobin, transferring, ceruloplasmin, and immunoglobulin. Due to the large size of the protein molecules, (5) they can be separated from the plasma by ultracentrifugation (unlike electrolytes or other smaller molecules). (6) They are unable to pass across the capillary membrane and consequently exert an oncotic pressure of about 25 mm Hg. (7) Owing to their size and particularly their shape, they greatly contribute to blood viscosity. The plasma protein fibrinogen is a significant contributor to blood viscosity. Due to the presence of polar residues on their surfaces, (8) the protein molecules are soluble in water. (9) The molecules show electrophoretic mobility. (10) The molecules are amphoteric. This is because the polar residues comprise both NH2 and COOH groups.
What are the the properties of plasma?
(1) Plasma proteins are large molecules with molecular weights ranging mostly from 50,000 to 300,000 Daltons. (2) With the notable exception of albumin, nearly all plasma proteins are Glycoproteins, containing oligosaccharides. The oligosaccharide chains are responsible for certain properties of plasma proteins like solubility, viscosity, charge, denaturation etc. (3) like most other proteins, their charged residues tend to be located on the surface. (4) Many plasma proteins exhibit polymorphism. Polymorphism is a Mendelian trait that exists in the population in at least two phenotypes, neither of which is rare. Plasma proteins showing polymorphism are haptoglobin, transferring, ceruloplasmin, and immunoglobulin. Due to the large size of the protein molecules, (5) they can be separated from the plasma by ultracentrifugation (unlike electrolytes or other smaller molecules). (6) They are unable to pass across the capillary membrane and consequently exert an oncotic pressure of about 25 mm Hg. (7) Owing to their size and particularly their shape, they greatly contribute to blood viscosity. The plasma protein fibrinogen is a significant contributor to blood viscosity. Due to the presence of polar residues on their surfaces, (8) the protein molecules are soluble in water. (9) The molecules show electrophoretic mobility. (10) The molecules are amphoteric. This is because the polar residues comprise both NH2 and COOH groups.
