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Antidiuretic hormone (ADH), or vasopressin, is a substance produced naturally by the hypothalamus and released by the pituitary gland. The hormone controls the amount of water your body removes.
Ectopic ADH secretion is the release of ADH from an abnormal location within the body. Ectopic means "out of place."
Alternative NamesSIADH; Syndrome of inappropriate antidiuretic hormone secretion
Causes, incidence, and risk factorsThe most common cause of ectopic ADH secretion is cancer. Certain lung cancers, as well as some head and neck tumors, are the most common cancers that cause this problem. In rare cases, many other tumors may cause ectopic ADH secretion.
See also:
SymptomsThe abnormal release of ADH makes it harder for the body to remove water. Fluid builds up in the body. Low blood sodium levels (hyponatremia) can occur.
Often, there are no symptoms from low sodium levels. However, changes in mental status and even seizures may occur.
TreatmentTreatment is aimed at removing the cause of the problem (for example, surgery to remove a tumor producing ADH).
Limiting fluid intake is another common treatment. This helps prevent excess water from building up in the body.
Patients in the hospital with ectopic ADH that does not respond to other treatments may be given tolvaptan by mouth (orally) and conivaptan through a vein (intravenous). These treatments block the effects of ADH.
ReferencesLin M, Liu SJ, Lim IT. Disorders of water imbalance. Emerg Med Clin North Am. 2005;23(3):749-770.
Gagel RF. Endocrine manifestations of tumors: "ectopic" hormone production. In: Goldman L, Ausiello D, eds. Cecil Medicine. Philadelphia, PA: Saunders; 2007:chap 188.
What else can I help you with?
Alcohol inhibits the secretion of what hormone?
Alcohol can inhibit the secretion of antidiuretic hormone (ADH), also known as vasopressin. ADH is produced in the hypothalamus and helps regulate the balance of water and electrolytes in the body by controlling water reabsorption in the kidneys.
What is the disease caused due to failure of ADH secretion?
Diabetes insipidus
What conditions decrease the secretion of ADH?
Secretion of antidiuretic hormone (ADH), also known as vasopressin, decreases under conditions such as low plasma osmolality, which occurs when there is excessive fluid intake or overhydration. Additionally, conditions that stimulate the body's diuretic response, such as the use of certain medications (like diuretics), or the presence of alcohol, can also reduce ADH secretion. Furthermore, stressors like adrenal insufficiency or certain diseases can inhibit ADH release.
What medical condition would describe an inadequate secretion of ADH?
Diabetes insipidus
What stimulates adh secretion from the posterior pituitary?
ADH secretion is stimulated by factors such as dehydration, high blood osmolality, low blood pressure, and stress. These conditions trigger the hypothalamus to release ADH from the posterior pituitary gland to help regulate water balance in the body.
Changes in blood osmotic pressure would most affect the secretion of?
Changes in blood osmotic pressure would most affect the secretion of antidiuretic hormone (ADH) by the pituitary gland. ADH helps regulate the concentration of urine by increasing water reabsorption in the kidneys, and its secretion is influenced by blood osmotic pressure to maintain water balance in the body.
Neurohypophyseal secretion of stimulates formation of concentrated urine?
The neurohypophyseal secretion of ADH (antidiuretic hormone) promotes water reabsorption in the kidneys, leading to the formation of concentrated urine. ADH acts on the collecting ducts of the nephrons in the kidneys to increase their permeability to water, allowing the body to conserve water and produce concentrated urine.
What is ADH and how is its secretion controlled by negative feedback?
ADH (antidiuretic hormone) is a hormone released by the pituitary gland that helps regulate water balance in the body by controlling the reabsorption of water in the kidneys. Its secretion is controlled by negative feedback, where rising blood osmolarity or a decrease in blood volume triggers release of ADH to help conserve water and decrease urine output, while decreasing blood osmolarity or an increase in blood volume suppresses ADH secretion.
Does alcohol alter ADH and Aldosterone?
Alcohol (ethanol) acts on the hypothalamus to inhibit ADH secretion. This leads to diuresis and the typical repeated trips to the bathroom while at the bar drinking.
When the concentration of water in body fluids increases the secretion of ADH increases.?
When the concentration of water in body fluids increases, the body's osmotic balance is affected, leading to a decrease in blood osmolarity. In response, the hypothalamus detects this change and signals the posterior pituitary gland to reduce the secretion of antidiuretic hormone (ADH), not increase it. Reduced ADH levels result in decreased reabsorption of water in the kidneys, promoting the excretion of excess water and helping to restore osmotic balance. Thus, an increase in water concentration actually leads to a decrease in ADH secretion.
What causes hypo-secretion of ADH?
Hypo-secretion of antidiuretic hormone (ADH) can be caused by conditions such as diabetes insipidus, which may be due to damage to the hypothalamus or pituitary gland, leading to decreased production or release of ADH. Other causes could include tumors, head injuries, or certain medications affecting the function of the pituitary gland.
What are Factors that increase the secretion of antidiuretic hormone?
Factors that increase the secretion of antidiuretic hormone (ADH) include dehydration, pain, stress, certain medications, and low blood pressure. ADH helps the body conserve water by reducing urine output when these factors are present.
