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Both Amoxicillin and Cephalexin are prescribed medications that would be issued under the treatment of a physician. Therefore, a physician would have to give the directive to use both antibiotics simultaneously. It is unlikely that any physician would prescribe both at the same time. More importantly, both Amoxicillin and Cephalexin are antibiotics, often used to treat the same diagnosis such as urinary tract infection or a sinus infection. What differentiates them is their spectrum classification that relates to their inherent effectiveness to the level of infection.

Amoxicillin is a narrow-spectrum antibiotic, treating a smaller range of bacteria than the broad-spectrum antibiotic, Cephalexin. Narrow-spectrum antibiotics tend to be lower in cost, and are often considered the first line of defense especially in milder case infections. When Amoxicillin is ineffective in combating the infection, Cephalexin may be prescribed for a more aggressive course of action due to its broader range of bacteria effectiveness.

It would be superfluous to use both Amoxicillin and Cephalexin as their mechanism of action is similar, the disruption of bacterial cell wall synthesis. And given the additive side-effects of using both and the risks of antibiotic resistance developing, it may also be considered irresponsible.

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