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Yesterday morning I took 150mg Wellbutrin and 2 teaspoons of Delsym cough syrup and within an hour I was feeling dizzy (sort of out of it). This feeling lasted all day and I still feel a little hazy this morning. My physician was knew I have been taking Wellbutrin for several years when he recommended Delsym for a cough caused by a sinus infection. I wouldn't recommend combing these two medicaions.

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Delsym has Dexthromethorphan Polystirex in it and although it was a really low dose you could be someone really sensitive to DXM but you should keep in mind Wellbutrin (Bupropion) interacts with DXM. Wellbutrin raises blood plasma levels and inhibits the liver from taking it out of your body. Thus resulting in the effect of Dextromethorphan being magnified and extended!

"Wellbutrin (bupropion) is a potent CYP2D6 enzyme (which metabolizes dextromethorphan) inhibitor. CYP2D6 inhibition slows down the conversion of dextromethorphan --> dextrophan, and therefore increases the ratio of DXM to DXO, resulting in a more experience with an increased amount of adverse side effects. Some users have reported that the combination of these two drugs can lead to experiencing effects for several days, and there have been reports of people on bupropion taking therapeutic doses of DXM and getting effects comparable to a low recreational dose level."

I personally used to abuse this combination because of this fact. Just so I could be high for days, if i had not gone to rehab I am certain I would be dead just like my best friend.

Fixing this is easy, take a much lower dose than stated on the bottle. And, please... avoid driving until you are certain you are not over medicated. Or talk to your doctor to find a cough medicine alternative.

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Wiki User

10y ago

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