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The active ingredients in Advil Cold and Sinus as of August 2016 are ibuprofen and pseudoephedrine. Some cough syrups also contain ingredients like pseudoephedrine, and doubling up on those ingredients may cause side effects, particularly for those with heart problems or high blood pressure. If you choose a cough medicine that only contains guaifenesin, or guaifenesin and dextromethorphan, you won't experience drug interactions with Advil Cold and Sinus.

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9y ago

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