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It is not a good idea to drink when you are using any non-steroidal anti-inflammatory drug (NSAID) such as ibuprofen, aspirin or naproxin sodium. There is risk of a severe stomach irritation, and possible ulcers if done continuously, since these drugs reduce the production of the mucous that protects the stomach lining and intestines from the effects of stomach acid.

Acetaminophen (Tylenol) should not be taken with alcohol at all. There is a distinct chance of permanent liver damage.

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15y ago

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