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You should not mix Acetaminophen (Tylenol) and Acetylsalicylic acid (Aspirin). The reason for this is long term renal (kidney) damage. What happens in the Tylenol induces the formation of free oxide radicals which damage tissues (especially the kidneys and liver). This is normally not an issue at low Tylenol doses.

However, when you add Aspirin to the mix, the free oxide radicals become an issue. Aspirin is a Cyclooxygenase inhibitor (COX), which decreases prostaglandin (PGE 2) synthesis. Prostaglandins are responsible for vasodilatation of the renal afferent arterioles. If you are on Aspirin the renal afferent arterioles are vasoconstricted and subsequently renal blood flow is decreased. When renal blood flow is compromised your kidney is less able to deal with the free oxide radicals produced by Tylenol.

So what happens?

The free oxide radicals damage the renal medulla (which may slough off) or lose the ability to concentrate urine due to damage to the most notably the thick ascending limb of the nephron. This is called Analgesic Nephropathy.

Having said this, the damage is caused by long term mixing of Tylenol and Aspirin, so having mixed the two in the past once five years ago is not going to compromise your kidneys. Just make sure to avoid the mistake in the future, and pass on this information (there are way too many sources providing incorrect information on this subject).

If you're having pain that bad, maybe your doctor can prescribe something stronger or more effective. It's very important not to exceed the recommended daily dose of either medication. Like prescription medications, there are side effects to medications that you can buy over the counter. When you have questions about medications, the best person to ask is a pharmacist. You can call any drugstore and speak to one, you don't have to be a customer.

Yes you can take both together (called polypharmacy) There used to be an over the counter med called Vanqish. It had aspirin/acetaminophen (TYLENOL) and caffeine. The Tylenol compliments the aspirin and the caffeine helps aspirin work better. BUT don't take high doses of each--take like 325 mg. Tylenol and 325 mg aspirin. If aspirin bothers your stomach, buy coated aspirin, called enteric aspirin. It dissolves in your intestine instead of your stomach. Generic enteric coated aspirin from a place like Wal*Mart is inexpensive. Also save your money and buy generic Tylenol (acetaminophen). Long term use (within reason) should not be a problem.

Do not use Tylenol (acetaminophen) with any other products containing acetaminophen. You can exceed daily recommended limits and cause liver damage. Read all labels carefully (cough syrup, etc.).

Advice from a US licensed pharmacist is that it is safe to take acetaminophen and aspirin together as long as you follow the recommended dosages of either and have no Allergies to either or conditions that would preclude your taking of either of these medications. As above, do not use acetaminophen with any other products containing acetaminophen.

Apparently so, since the active ingredient in Tylenol, acetaminophen, is used in combination with aspirin, in Anacin Advanced (250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine.)

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11y ago

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