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the painkilling ingredient in Fioricet is acetaminophen; ibuprofen is an anti-inflammatory drug that reduces hormones within the body that cause inflammation and pain. Ibuprofen does not interact negatively with the painkiller in Fioricet. Therefore; it is safe to take ibuprofen and Fioricet at the same time as long as you stay within the recommended dosage for each.

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13y ago

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