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The combination of ibuprofen (Advil, Motrin) and phenylephrine hydrochloride (a common decongestant in nasal sprays and cold medicines such as Sudafed) has no indicated drug interaction.* However, if you have never taken either, or take other medications, you should consult a medical professional about dosages, side effects, or possible interactions with other prescription or over-the-counter medications.

* The drug ibuprofen is used in combinations with drugs such as chlorpheniramine maleate and pseudoephedrine hydrochloride, as in Advil Allergy Sinus. There is a risk of interaction with the pseudoephedrine HCl in such products, so mixing decongestants (sprays and/or oral) should not be done without a doctor's approval.

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9y ago

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