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Many over-the-counter and behind-the-counter analgesics formulated specifically for headache contain caffeine. In the USA, probably the best known of these is Excedrin. Also, composition tablets known as "Tylenol #1" and "Tylenol #2" in the USA, and as "Compound 222" in Canada, contain caffeine in addition to aspirin and small dosages of codeine. Caffeine arguably works for to relieve certain headaches: those associated with caffeine withdrawal. The efficacy of caffeine in other headache types is controversial.

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