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ACE inhibitors reduce blood pressure by causing less aldosterone and antidiuretic hormone to be released, resulting in more water output and a lowering of the blood volume, which lowers the blood pressure.

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What effect on the treatment of secondary hypertension would you expect from angiotensin-converting enzyme inhibitor drugs?

Angiotensin-converting enzyme (ACE) inhibitors are effective in treating secondary hypertension, particularly when the condition is linked to conditions like renal artery stenosis or endocrine disorders. By inhibiting the conversion of angiotensin I to angiotensin II, these drugs help to relax blood vessels, reduce blood pressure, and decrease the workload on the heart. Additionally, they can improve kidney function in patients with hypertension related to renal issues. Overall, ACE inhibitors can significantly lower blood pressure and mitigate complications associated with secondary hypertension.


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Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure. It is not extensively metabolized by the liver; instead, it is primarily excreted unchanged by the kidneys. The drug's pharmacokinetics allow it to have a prolonged half-life, leading to effective blood pressure control with once-daily dosing. Its action involves inhibiting the conversion of angiotensin I to angiotensin II, resulting in vasodilation and reduced blood pressure.


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What medication helps lower systolic pressure?

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