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Thalidomide regulates the immune response by suppressing a protein, tumor necrosis factor alpha.

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Did they trail the drug thalidomide?

Yes - there are thousands of deformed people as proof of the Thalidomide trials ! The drug Thalidomide was initially marketed as a cure for 'morning sickness' associated with early pregnancy. HOWEVER - the drug also caused deformities in the developing embryos, resulting in mental an physical abnormalities. There was a huge legal battle to get the makers of Thalidomide to accept responsibility for the flaw in their product. See the related link to Wikipedia for a detailed article on the drug - and its consequences.


What is the name of the drug that made pregnant women's baby's deformed?

Thalidomide


Drug of choice for type 2 lepra reactions?

Thalidomide Steroids


What drug was used in Europe and distributed in the US as a sedative for pregnant women?

Thalidomide.


What are some books about the thalidomide disaster?

Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine by Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicineby Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom


What is a lethal drugs?

Any drug that will kill you if taken in excess. This includes most drugs, even aspirin. A non-lethal drug would be Thalidomide. One person attempting suicide by Thalidomide woke-up a month later with a head-ache. Interestingly pregnant women taking Thalidomide will have severely deformed children - so its a complex situation.


Why did German drug company expect to make a lot of money from thalidomide?

Because that is the purpose of a drug company, to make money from the drugs they manufacture


When and how was thalidomide baned?

Thalidomide was banned in most countries in the early 1960s after it was linked to severe birth defects when taken by pregnant women. The drug was initially introduced in the late 1950s as a sedative and treatment for morning sickness but was withdrawn from the market in 1961 following widespread reports of its harmful effects. Regulatory agencies, including the U.S. Food and Drug Administration (FDA), imposed strict regulations on drug testing and approval processes as a result of the thalidomide tragedy. Today, thalidomide is still used under strict controls for certain conditions, such as multiple myeloma, but is prohibited for use in pregnant women.


Now used to treat leprosy what chemie grunenthal drug produced a birth defect called phocemelia?

thalidomide


What is the effect on babies by thalidomide?

Thalidomide, a drug initially prescribed for morning sickness in pregnant women during the late 1950s and early 1960s, caused severe birth defects in babies, including limb malformations, organ abnormalities, and facial deformities. Known as phocomelia, the most notable effect was the underdevelopment of arms and legs. The tragedy led to stricter regulations on drug testing and approval for pregnant women. Today, thalidomide is used under strict controls for certain conditions, but it remains a poignant reminder of the importance of drug safety.


How did thalidomide cause birth deformities?

This occurred due to the fact that the first manufacturer of thalidomide was a German pharmaceutical company - which first sold this drug in October of 1957. This was followed by British approval of the drug. Subsequently, over the next ten years or so, about 2,500 "thalidomide babies" were born in Germany, and about 2,000 in Great Britain. The birth defect is called phocomelia, a shortening of the limbs, in which they appear to look like the flippers on a seal. Also, the FDA did not approve thalidomide in the U.S. (although quite a few tablets found their way to the U.S., despite the FDA ban).


When was thalidomide found to be dangerous?

Thalidomide was found to be dangerous in the early 1960s when it was linked to severe birth defects in thousands of children born to mothers who took the drug during pregnancy. The drug, initially marketed as a sedative and treatment for morning sickness, was withdrawn from the market in 1961 after reports of its teratogenic effects emerged. The scandal led to significant changes in drug approval processes and regulations worldwide.