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Zoloft (sertraline) is primarily metabolized in the liver through the cytochrome P450 enzyme system, particularly CYP2B6 and CYP2C19. Its metabolites are further conjugated and then excreted mainly through the urine. A smaller portion is eliminated in feces. The drug's half-life is approximately 24 hours, which supports once-daily dosing.
What else can I help you with?
What percentage of ingested alcohol is NOT metabolized in the livers but is excreted unchanged?
The percentage of alcohol that is not metabolized in the liver and excreted unchanged is between 2 and 10%.There is a slight range due to body size and amount of alcohol ingested.
How is sumatriptan metabolized and excreted?
Sumatriptan is primarily metabolized in the liver by enzymes into its primary metabolite, known as IN-1237. The metabolites are then eliminated predominantly through the urine as inactive compounds. Only a small percentage of the unchanged drug is excreted in the urine.
How do crystal methamphetamines leave your body?
Methamphetamine is metabolized into other chemicals, and then excreted from the body in the urine.
Does THC come out in poop?
Yes, THC can be detected in feces as it is excreted from the body through urine and feces after being metabolized.
Where is Ibuprofen metabolized?
Ibuprofen is metabolized by the Kidneys and is thus excreted in the Urine. Actually, "...NSAIDs are metabolized by the liver via oxidative and conjugative pathways and have the potential to cause liver injury, with some agents being more hepatotoxic than others" Source: http://www.uic.edu/pharmacy/services/di/liver.htm
Is It True That Most Drugs Are Eliminated By The Kidneys In Urine Although Some Are Excreted In Saliva Sweat Or Exhalation?
Most drugs are either excreted in the urine (via the kidneys) - particularly if they are very water soluble - or sometimes metabolized - mostly in the liver.
Why is the disk diffusion technique not a perfect indication of how a drug will perform in vivo?
Variable such as serum, body pH, ionic content, O2 level are not tested. Also you can not tell how the drug is metabolized and excreted or the side effects of the drug.
How is nicotine excreted?
Nicotine is primarily metabolized in the liver, where it is converted into several metabolites, with cotinine being the most prominent. Once metabolized, nicotine and its metabolites are excreted primarily through the kidneys in urine. A smaller amount may also be eliminated through saliva, sweat, and breast milk. The excretion rate can be influenced by factors such as pH levels, age, and individual metabolic differences.
Is Valium metabolized by the kidneys?
No, Valium (diazepam) is primarily metabolized by the liver, not the kidneys. The liver converts diazepam into active metabolites, which are then excreted by the kidneys. While the kidneys play a role in eliminating these metabolites from the body, they are not involved in the primary metabolic process of Valium itself.
Are intravenous drugs metabolized?
Most are, the vast majority of drugs being broken down by the liver. Some (e.g. lithium carbonate) however are simply excreted without modification though the kidneys.
How is peptobismol metabolized in the body?
Pepto-Bismol, which contains bismuth subsalicylate, undergoes minimal metabolism in the body. Bismuth is mostly excreted unchanged in the feces, while salicylate, a component of the compound, is absorbed and metabolized in the liver. Salicylate can be conjugated to form various metabolites, including salicyluric acid, which are then excreted in the urine. Overall, the primary mechanism of action is local, providing relief in the gastrointestinal tract rather than systemic metabolism.
What are the final two products of alcohol metabolism which are excreted from the body?
The final two products of alcohol metabolism are acetaldehyde and acetic acid. Acetaldehyde is further metabolized to acetic acid, which is then converted into carbon dioxide and water. These final products are excreted from the body primarily through urine and respiration.
